A controlled trial in resistance-trained men found that resting 3 minutes between sets produced greater strength and muscle thickness gains than resting 1 minute, because longer rest preserved the volume-load completed in subsequent sets. Very short rest can compromise the total work performed.
- Schoenfeld BJ, Pope ZK, Benik FM, et al. (2016). Longer Interset Rest Periods Enhance Muscle Strength and Hypertrophy in Resistance-Trained Men doi:10.1519/JSC.0000000000001272